Endocannabinoid Signaling in Autism

Editor's Notes

1. It’s important for me to have a conversation with all of you, so this presentation will be made available for any of you – please go to my site and sign-up, and I’ll send along next week.
2. How many parents have a child with Autism? Me too… My son has autism, 12 years old How many parents are beat? Tired? Feel helpless? I’m in the same boat….. What have you tried? ABA? GF/CF/SF IV/IG HBOT Horse Riding Music Therapy How many have tried soooooo many thing? Then I heard about cannabis…..and I’d like to share with you what I learned… ** SHOW VIDEO **
3. John Hopkins UCLA All within the last 10 years
4. From a lot of these studies, and also when you look into the realms of epilepsy, you can see the piriform cortex in epileptics and the cerebellum in autistics to be involved. PiC and neuronal loss and severe gliosis are reported in all layers following death by status epilepticus [Primary olfactory cortex in autism and epilepsy: increased glial cells in autism, Oxford, UK]. 17 studies I found in which almost all autistic subjects that were tested showed evidence of brain inflammation. The cerebellum is involved in a substantial number of complex functions, ranging from the coordination of movements to language processing, spatial cognition, and other higher cognitive and affective functions  Damage to the cerebellum typically leads to motor deficits, but it can also result in cognitive impairments such as loss of working memory and verbal fluency, and they are associated conditions such as autism and dyslexia.
5. Coordination of movements language processing spatial cognition loss of working memory
6. Aluminum has been around since the 1920s. But why the raise of autism in the 1990s? Because adjuvants directly cause inflammation of the brain. And Glyphosate will make sure it stays this way.
7. The oddest thing about vaccines is that it contains human tissue. I always thought this was too crazy to be true, but it is right there on the government’s website. MRC–5 for example is a diploid human cell culture line composed of fibroblasts derived from lung tissue of a 14 week old aborted Caucasian male fetus HEK-293: cells were generated in the early 1970s.The human embryonic kidney cells were obtained from previously healthy aborted fetus
8. WI38: lung fibroblasts, coming from a female fetus that was aborted at 3 months gestation because the family felt they had too many children (G. Sven et al., 1969) Rubella ingredient is called RA 27. R=rubella, A=abortus, 27=27th fetus, 3=third tissue culture explant (from the baby’s kidney). 80 separate, elective abortions recorded were involved in the research and final production of the present day rubella vaccine
9. More evidence that the cerebellum is likely the target of vaccine adjuvants is that the lateral hemispheres engaged in cognitive processing mature particularly late [129]. This renders the cerebellum vulnerable to environmental influences such as vaccine adjuvants.
10. 29 states have some sort of recreational and/or medical marijuana law For autism we only have 2 pure states. PA and GA. Delaware is only for adults. The rest have it possible for any debilitating condition. AZ,SC,MARYLAND and MI are currently applying
11. From 1850 to 1937, cannabis was used as the prime medicine for more than 100 separate illnesses or diseases in US Pharmacopeia
12. On the National medical libray, Pubmed, I found this many peer reviewed articles when searched: Cannabis: 16,413Marijuana: 25,348There is lots of books, written by the leaders in the research realms like Dr. Mechoulam, Russo, DiMarzo and others
13. 22.2 million people have used it in the past month) according to the 2015 National Survey on Drug Use and Health. I see reports all over the news about cannabis overdoses and deaths. No I dont
14. Therapies based on endogenous molecules are a mainstay of medicine. The hormone insulin was successfully given to patients with diabetes shortly after its discovery. And cortisone-based medicines can be used to relieve pain and reduce swelling
15. This horrible paper from Australia.
16. he Mayo Clinic is participating in clinical trials of cannabidiol for medication-resistant seizures in very specific patient populations. A subset of children and young adults with Dravet’s Syndrome or Lennox-Gastaut Syndrome will be eligible. For more information, contact pediatricepilepsyresearch@mayo.edu. Gillette Children’s Specialty Healthcare is participating in Phase 3 clinical trials that will enroll patients with Lennox‐Gastaut Syndrome (LGS) or Dravet Syndrome with inadequately controlled seizures. Please use the following links to clinicaltrials.gov for more specific study information and study eligibility. 
17. The FDA approved Marinol in 1985 for the treatment of nausea and vomiting associated with cancer chemotherapy as well as appetite stimulation. It is approved in Denmark for multiple sclerosis since 2003. Approved in Canada for AIDS-related anorexia (Apr. 2000) and for nausea and vomiting associated with cancer chemotherapy (1988). 2006: FDA approval of Cesamet in 2006 for nausea and vomiting in patients undergoing cancer treatment. Also approved in United Kingdom and Australia (1982), Canada (1981), and Mexico (2007).  The FDA will soon grant a license to GW Pharmaceuticals for treating patients with multiple sclerosis with a drug called Epidiolex, probably in September. Epidiolex, reduced the frequency of seizures by 39% in children with a severe form of epilepsy known as Dravet syndrome. Sativex is still awaiting approval from the FDA for severe pain treatment for cancer patients only when pain can’t be relieved with strong opioids. Approved to treat spasticity caused by multiple sclerosis in Spain (July 28, 2010), Canada (Aug. 31, 2010), Czech Republic (Apr. 15, 2011), Denmark (June 8, 2011), Germany (July 4, 2011), Sweden (Dec. 22, 2011), Austria (Feb. 7, 2012), Italy (May 7, 2013), and Switzerland (Nov. 27, 2013). Also approved in Finland, Israel, Norway, and Poland.  concentrating on severe, orphan, early-onset, treatment-resistant epilepsy syndromes including Dravet syndrome, Lennox-Gastaut syndrome (LGS), Tuberous Sclerosis Complex (TSC) and Infantile Spasms (IS). There is currently 6 more of these in advanced trials then waiting for approval.
18. The FDA approved Marinol in 1985 for the treatment of nausea and vomiting associated with cancer chemotherapy as well as appetite stimulation. It is approved in Denmark for multiple sclerosis since 2003. Approved in Canada for AIDS-related anorexia (Apr. 2000) and for nausea and vomiting associated with cancer chemotherapy (1988). 2006: FDA approval of Cesamet in 2006 for nausea and vomiting in patients undergoing cancer treatment. Also approved in United Kingdom and Australia (1982), Canada (1981), and Mexico (2007).  The FDA will soon grant a license to GW Pharmaceuticals for treating patients with multiple sclerosis with a drug called Epidiolex, probably in September. Epidiolex, reduced the frequency of seizures by 39% in children with a severe form of epilepsy known as Dravet syndrome. Sativex is still awaiting approval from the FDA for severe pain treatment for cancer patients only when pain can’t be relieved with strong opioids. Approved to treat spasticity caused by multiple sclerosis in Spain (July 28, 2010), Canada (Aug. 31, 2010), Czech Republic (Apr. 15, 2011), Denmark (June 8, 2011), Germany (July 4, 2011), Sweden (Dec. 22, 2011), Austria (Feb. 7, 2012), Italy (May 7, 2013), and Switzerland (Nov. 27, 2013). Also approved in Finland, Israel, Norway, and Poland.  concentrating on severe, orphan, early-onset, treatment-resistant epilepsy syndromes including Dravet syndrome, Lennox-Gastaut syndrome (LGS), Tuberous Sclerosis Complex (TSC) and Infantile Spasms (IS). There is currently 6 more of these in advanced trials then waiting for approval.
19. Food-derived flavonoids, such as luteolin, apigenin, and quercetin Polyunsaturated fatty acid (PUFA) DHA SCFA (butyrate) Kaempferol